I encountered this question's answer and my question is somewhat related, though not entirely answered over there.
I recently graduated, and have almost a year of experience doing a PhD before dropping out (I had my reasons). Anyway, there's a company located near which I would like to work for. They are advertising senior positions which are R&D oriented, but require skills obtained in industry. So preferably PhDs with extra industry experience. Not selling myself short, but I definitely do not meet the description. Most if not all their vacancies are like that, and they do not mention accepting graduates.
In summary: What is the strategy for open application - enough threads and info on that - when the company seems only interested in senior profiles.
And would that even be a good idea? There are enough vacancies for me to apply elsewhere, and I think one option is indeed to gather experience in the industry and revisit this idea in a couple years?