There's a time and place for humor - and realistically ninety nine times out of a hundred your LinkedIn profile isn't it. I'm guessing you wouldn't use this line on your CV so that begs the question of why would you use it on your LinkedIn?
Because exactly like your CV, LinkedIn is somewhere you're generally putting your "professional" facade on, and just like no-one expects people to be wearing a suit and tie all the time they probably still expect you to wear one for an interview.
The profanity isn't the problem but rather the irreverent tone - and the impression that you perhaps don't "get" professional norms of communication. Were I hiring candidates and saw that I'd possibly even chuckle at the line, I loathe Excel getting misused far beyond it's intended purpose as much as the next guy - and then I'd start having concerns that you might have a tendency to open your mouth and put your foot in it.
Say there was a hypothetical scenario where you might be in a meeting with some client or potential client and they're a bit on the formal side. We do a round-robin introduction of personnel and roles and you said
I'm johnDanger, I'm helping scientists escape Excel hell, one spreadsheet at a time
If the client shares your humor they might have a chuckle, it might even be a great ice-breaker. If they don't you just committed a gaffe, and while representing the company no less. So it's potentially pretty darn cringey.
That's the problem with humor, it's not universal, and that makes it a (potential) minefield with people you don't know, and particularly where there isn't much context.
You might take the view that if someone is going to get all bent out of shape over what is really a very mild comment that you'd rather not work with them in the first place. And there's nothing wrong with taking that stance - so long as you're aware of that effect and are prepared for it.