This is not a point of view: I participate on a lot of interviews and selection process, but i worked for the gaming industry. So it may be a lot different from common software development companies, or other business in general.
We had one person to take care of the HR in our company. This person handled all CV's and Portfolios that were handed to us.
But we used the CV for almost nothing - what we did was search on the web about the person itself. Profiles on websites like deviant, newgrounds and gamedev for junior developers and moby for seniors. I helped with technical analysis of the person past jobs.
The CV was only a Formality and something we used to remove those that we would not even "waste" (because it's never really a waste) our time interviewing them.
But when we gave the CV the first look, and we saw holes in your working timeline, we will ask for them, and what they are about. Why there is nothing between your job 1 and 2? Even they have a year of difference? I used to help on these kind of questions on the interviews.
So, some companies will surely look with more details at holes at the CV.
But it's not a big deal - just be ready to answer questions.
“In the information age, the barriers just aren’t there"
And that means (the following is just my point of view), in this case, that holes in your CV won't be what will define if you get the job or not. At least not if you don't lie about them if asked!