This will vary based on the personality and experience of the people doing the interviewing, but in general, the people at the top are more concerened with your fit into the organziation and tend to ask more soft skills questions that demonstrate how well you work with people and solve problems. If the job will have client contact, they are particularly interested in how you will be perceived by a client, so they will be looking closely at your grooming, your eye contact, your handshake, your manners (especially if food is served during the interview), your word choices as well as the content of your answers. You are representing them to the client and they want to make sure you would not embarrass them.
I remember one interview we did where the person looked beautifully polished and professional and had a good written resume for an entry level person and she lost the job in less than a minute when she started talking because she couldn't say a sentence without using the word, "like". ("Like, you know, I would be the best candidate becasue..."). Since we had extensive client contact with senior level people, we passed on her.
The direct supervisors tend to concentrate more on technical skills. However, the soft skills are important to the immediate supervisor as well and at entry level, they may be far more important as there is not a high expectation of technical skills at that level.