It depends on how you are listing the technologies and whether the technologies you are no longer interested in have some relationship to technologies that you are interested in.
Frequently, technologies that you have used in the past have some sort of relationship to technologies that you want to use today that you can use to demonstrate a deeper level of experience. For example, imagine that you spent 5 years doing C++ development before moving on to Java development for the past 3 years and that you are only interested in doing Java development today. It would still be very much in your interest to list your experience with C++ because that lets you position yourself as having 8 years of experience doing object oriented development with the last 3 in the particular language you are interested in. That is going to be much more interesting to an interviewer than someone with just 3 years of Java development.
Older technologies are often also useful to help you check off some of the technologies that companies list as "nice to have" by showing that you've done something similar. If a company is looking for a Java developer and lists Perl as a "nice to have", it can be helpful to be able to point to a bit of Python development that you've done and talk about the similarities between the two languages. Even if you are not interested in writing Python any longer, your experience can be leveraged to discuss your ability to write Perl in the future.
It will also depend on where and how you are listing the technologies. If you have a section on your resume where you list the languages you're familiar with, your years of experience, your level of expertise, etc. it's much more likely that you want to omit technologies that you don't want to be quizzed on. If you are talking about the portion of your resume where you list the jobs you've held, what you did in each position, what technologies you used, etc. it would be very odd to omit the major technologies that you used even if you are no longer interested in those technologies. Unless the position is so old that you remove it entirely, you'll want to talk about the technologies that you used. If you're the hypothetical C++ to Java developer I was discussing earlier, it would make sense to discuss your use of C++ when describing your previous job but it might make sense to omit C++ from the section of your resume that focuses on skills and to just emphasize the technologies you do want to use. Even in the skills section, though, you may want to leverage some of those old technologies by, for example, explicitly listing 8 years of experience with object-oriented development.