Developing a "personal brand" can be advantageous if you're involved in many communities or groups, and if you're blogging or doing any kind of independent, freelance, or consulting work.
Since your resume/CV will be photocopied multiple times, colors are only important to the extent that they copy well to grayscale or black and white. Don't rely on color to convey important information on the page. If you can, provide your resume in a ready-to-print format, such as PDF. If you must provide a Word document, expect that your special fancy font will not be installed on anyone else's computer, and your resume may look bad if they print it from their computer.
Things like whitespace, fonts, and alignment are important. I had what I thought was a pretty good looking page until I saw what my graphic designer brother did to it. He said he hit it with a "pretty stick" and I have to agree the result was better.
Ultimately, a well designed page won't win you as many points as a poorly designed page will cost you. But it's worth it to have someone who knows what they're doing look it over and tap it with a "pretty stick" if needed. It will help ensure you don't get cast aside based on an ugly page.