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I am applying for a particular position where they have asked me if I have first-hand experience in protein crystallization and x-ray structure determination. I don’t have experience in any of those but I have mentioned my other experiences as asked. I lack only these.

How should I positively reply back so that it conforms my position there?

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    "No, but in preparation for this interview, I've studied those topics. And I think they're rather similar to [blah blah], which I do have experience in." Sep 9, 2017 at 6:39
  • And if they ask you again, give them the theoritical bit and say, you are looking for more exposure in that area and would like to learn that area.
    – Ironluca
    Sep 11, 2017 at 13:16

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No one ever has all the skills needed for a given position, unless it is well below your skill level, in which case you might be rejected as overqualified!

What prospective employers almost invariably want to hear is: motivation, motivation and motivation :) Acknowledge that you lack these skills, but assure them you are eager to learn them and study the theory behind the subject. Usually people learn best by doing.

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