Once you have those years of experience, without too much hopping around most recruiters will stop looking at your education more and more. It's far more interesting to note what company someone worked for and what work they did, thenthan it is to see what they were doing all those years ago. Still though, when a recruiter gets a lot of applications, filtering on education is one of the two easiest things to do... but the other one is filtering on the years of experience. Which of those two will win out in general I can't tell you, but I think it's fair to say that getting a job at the most popular companies will be harder, because they will simply higher the person who is 5 years older than you are and has both the degree and the experience (and once you get to 20 years of experience vs 25 years... it really doesn't matter that much anymore).