If the side effects are going to be intense (they sound pretty serious), then maybe you should consider going on medical leave while you sort yourself out (discuss this with your psychiatrist).
If however, you're going to keep going in to the office, then you may indeed wish to inform your boss and/or HR that you're transitioning off some medication (with the blessing of your medical professional), and may experience some side effects which they should know about.
This situation is tricky because you would be voluntarily disclosing medical information. However, if you suddenly snap and yell at someone in the office it might not hurt for your boss to be aware that you don't "mean it", and might need some time alone to compose yourself, or to head home for the remainder of the day.
Either way, I would strongly suggest taking a few days off and monitoring your reaction to the withdrawal.